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    Exatecan mesylate (CAS 169869-90-3) is a potent camptothecin-derived topoisomerase I inhibitor used in anticancer research, cytotoxicity studies, and ADC payload development.
    Chemical structure of Exatecan mesylate , CAS 169869-90-3, AChemBlock 10484

    Exatecan mesylate

    Catalog ID: 10484

    Product Name: Exatecan mesylate
    CAS: 169869-90-3
    MDL: MFCD04113012
    Purity: 98%
    Appearance: white to beige
    FW: 531.56
    Formula: C₂₅H₂₆FN₃O₇S
    Smiles: CS(=O)(O)=O.O=C1[C@@](CC)(O)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5N)C(C)=C(F)C=C6N=C4C3=C2)=O
    Exatecan mesylate 98%, CAS#: 169869-90-3, Cat ID: 10484, REFERENCE COMPOUNDS, AChemBlock
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    For research use only. We do not sell to patients
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    update on 09-13-2026

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    Safety Information
    Safety Information
    Pictograms GHS07
    Signal Word Warning
    Hazard Statements Causes skin irritation
    Causes serious eye irritation
    May cause respiratory irritation
    Precautionary Statements Avoid breathing dust/fume/gas/mist/vapours/spray.
    Product Information
    Product Information
    Product Information
    Purity 98%
    Appearances white to beige
    Storage Store at 0-8 °C
    Shipping Room Temp
    MSDS Download MSDS
    IUPAC Name (1s,9s)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10h,13h-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione methanesulfonic acid salt
    HTS Code 2933790400
    Smiles CS(=O)(O)=O.O=C1[C@@](CC)(O)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5N)C(C)=C(F)C=C6N=C4C3=C2)=O
    InChiKey BICYDYDJHSBMFS-GRGFAMGGSA-N
    Product Description Exatecan mesylate (CAS 169869-90-3) is the mesylate salt of exatecan, a potent camptothecin-derived inhibitor of DNA topoisomerase I. It stabilizes the covalent complex formed between topoisomerase I and DNA, preventing re-ligation of single- strand DNA breaks and ultimately leading to replication-associated DNA damage and cell death. Exatecan has been widely investigated in anticancer research because of its strong cytotoxic activity against a variety of tumor cell types. Its highly potent exatecan scaffold is also used in the development of cytotoxic payloads and payload-linker systems for antibody-drug conjugates (ADCs). Exatecan mesylate is suitable for laboratory studies involving topoisomerase I inhibition, cancer biology, DNA damage mechanisms, apoptosis, cytotoxicity evaluation, drug discovery, and ADC payload research.
    Product Application Topoisomerase I Inhibitor Research; Anticancer Drug Discovery; ADC Payload Development; Cytotoxicity Studies; DNA Damage and Apoptosis Research
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